Spine ABC, A Multidimensional Case Report from A to Z: Aneurysmal Bone Cyst of the Spine
In memory of Dimitrios Konstantinou
Abstract
Background: Aneurysmal bone cysts (ABC) are uncommon entities which cause expansile and destructive bone lesions and are characterized by reactive proliferation of connective tissue. They usually grow rapidly with hypervascularity. ABC’s incidence on the spine is 1.5 in 10 million. Most cases present with pain of unexplained origin.
The Case: Presented in this paper is an ABC case in the spinous process of the L2 vertebra of a 20-year-old Greek female patient. The main symptom was persistent back pain, without neurological symptoms, of four years’ duration. Treatment consisted of surgical curettage of the lesion. In this case report, we tried to describe not only the pathology of this disease but also the subsequent psychosocial symptoms that accompany it. We managed to accomplish that by exploiting the knowledge of an experienced pathologist, the help of the physicians responsible for this case, the interest of some sensitized medical students, and of course, the experience of the patient herself since the patient is also the lead author.
Conclusion: The focal point of this article is that even though ABCs might lead to excruciating pain, this pain can be alleviated with the proper treatment, especially if the communication between physician and patient is optimal.
References
Schajowicz F. Aneurysmal bone cyst. Histologic Typing of Bone Tumours. Berlin: Springer-Verlag; 1992. 37.
.Leithner A, Windhager R, Lang S, et al. Aneurysmal bone cyst. A population based epidemiologic study and literature review. Clin Orthop Relat Res. 1999 Jun. (363):176-9.
Burch S, Hu S, Berven S. Aneurysmal bone cysts of the spine. Neurosurg Clin N Am. 2008 Jan. 19(1):41-7.
Kransdorf MJ, Sweet DE. Aneurysmal bone cyst: concept, controversy, clinical presentation, and imaging. AJR Am J Roentgenol. 1995 Mar. 164(3):573-80.
Cottalorda J, Bourelle S. Modern concepts of primary aneurysmal bone cyst. Arch Orthop Trauma Surg. 2007 Feb. 127(2):105-14.
Lau AW, Pringle LM, Quick L, Riquelme DN, Ye Y, Oliveira AM, et al. TRE17/ubiquitin-specific protease 6 (USP6) oncogene translocated in aneurysmal bone cyst blocks osteoblastic maturation via an autocrine mechanism involving bone morphogenetic protein dysregulation. J Biol Chem. 2010 Nov 19. 285(47):37111-20.
Guseva NV, Jaber O, Tanas MR, Stence AA, Sompallae R, Schade J, et al. Anchored multiplex PCR for targeted next-generation sequencing reveals recurrent and novel USP6 fusions and upregulation of USP6 expression in aneurysmal bone cyst. Genes Chromosomes Cancer. 2017 Apr. 56 (4):266-277.
Park HY, Yang SK, Sheppard WL, Hegde V, Zoller SD, Nelson SD, et al. Current management of aneurysmal bone cysts. Curr Rev Musculoskelet Med. 2016 Dec. 9 (4):435-444.
Schreuder HW, Veth RP, Pruszczynski M, et al. Aneurysmal bone cysts treated by curettage, cryotherapy and bone grafting. J Bone Joint Surg Br. 1997 Jan. 79(1):20-5.
Brastianos P, Gokaslan Z, McCarthy EF. Aneurysmal bone cysts of the sacrum: a report of ten cases and review of the literature. Iowa Orthop J. 2009;29:74-8
Engel GL: The clinical application of the biopsychosocial model. Am J Psychiatry 1980;137:535-544
María Dueñas, Begoña Ojeda, Alejandro Salazar, Juan Antonio Mico, and Inmaculada Failde A review of chronic pain impact on patients, their social environment and the health care system June 2016 Journal of Pain Research Volume 9(Issue 1):457-467
Kress HG, Aldington D, Alon E, Coaccioli S, Collett B, Coluzzi F et al. A holistic approach to chronic pain management that involves all stakeholders: change is needed. Curr Med Res Opin. 2015;31(9):1743-54
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