TY - JOUR AU - Mousa, Yazan S. PY - 2016/12/31 Y2 - 2024/03/29 TI - Autoimmune Lymphoproliferative Syndrome (ALPS): A Case Report JF - International Journal of Medical Students JA - Int J Med Stud VL - 4 IS - 3 SE - Case Report DO - 10.5195/ijms.2016.165 UR - https://ijms.info/IJMS/article/view/165 SP - 123-126 AB - <p><strong>Background:</strong> Autoimmune lymphoproliferative syndrome (ALPS) is a rare disorder of the blood, estimated at around 500 cases worldwide. It is characterized by a dysregulation of T-cells in the immune system, and is caused by a defect in the process that mediates leukocyte apoptosis. This may result in an increased risk of lymphoma and autoimmune diseases. <br><br><strong>Case:</strong> The author reports a case of an 11-year-old male who had been followed up since three years of age for recurrent cytopenias, occurring with intermittent breakouts of purpuric rash, nosebleeds, and prolonged infections. <br><br><strong>Conclusion:</strong> A probable diagnosis was made through criteria based on the First International ALPS workshop of 2009. This includes the presence of circulating double-negative T cells, considered the laboratory marker unique for ALPS. The mainstay of treatment was prednisone, given at doses varying in proportion to the severity of immunocytopenia. osis.</p> ER -