Seroprevalence of Hepatitis B Infection among First-Time Blood Donors in Faridpur, Bangladesh: A Cross-sectional Study
Background: Hepatitis B infection is a global threat for people of all age groups and is common in Bangladesh and other South Asian countries. Blood donors and blood donation can present important risk for hepatitis B infection. Our objective was to identify seroprevalence of hepatitis B virus among blood donors in Faridpur, Bangladesh. Methods: A cross-sectional study was conducted among 719 blood donors in the Faridpur district of Bangladesh from April to July 2013. Data was collected by non-probability convenient sampling maintaining inclusion and exclusion criteria. Face-to-face interview, blood grouping test, and hepatitis B surface antigen (HBsAg) screening were conducted. Results: About 30% of the blood donors were between 19 and 23 years of age, and 87.5% of them were males. Two-thirds (64.1%) of the donors were replacement donors, while the remaining 35.9% of them were voluntary donors. The overall seropositivity of HBsAg was found to be 1.5%. All infected blood donors were males. Hepatitis B infection was more prevalent in the 34–38 years age group and least prevalent among those older than 48 years of age. About 2% of replacement blood donors were infected with hepatitis B virus, compared to 0.7% among voluntary blood donors. Conclusion: Hepatitis B infection among blood donors is relatively lower than in other high-risk groups for hepatitis B infection in Bangladesh. Predominance of HBsAg among older adult groups, replacement donors, and the male gender can be a matter of public health concern.
2. Mahtab MA, Rahman S, Karim MF, Khan M, Foster G, Solaiman S, et al. Epidemiology of hepatitis B virus in Bangladeshi general population. Hepato¬biliary Pancreat Dis Int. 2008 Dec;7(6):595-600.
3. Khan M, Ahmed N. Seroepidemiology of HBV and HCV in Bangladesh [abs¬tract]. Int Hepatol Commun. 1996 May;5(1):27-9.
4. Deinhardt F. Serum markers of hepatitis viruses in natural disease and after vaccination. Prog Liver Dis. 1982;7:451-67.
5. Islam MN, Islam KM, Islam N. Hepatitis-B virus infection in Dhaka, Bangla¬desh. Bangladesh Med Res Counc Bull. 1984 Jun;10(1):1-6.
6. Rumi MA, Begum K, Hassan MS, Hasan SM, Azam MG, Hasan KN, et al. De¬tection of hepatitis B surface antigen in pregnant women attending a public hospital for delivery: implication for vaccination strategy in Bangladesh. Am J Trop Med Hyg. 1998 Aug;59(2):318-22.
7. Mustafa M, Islam MN, Rahman M, Salauddin AK. Prevalence of hepatitis B surface antigen (HBsAg) among parenteral drug abusers at Dhaka. Bangla¬desh Med Res Counc Bull. 1989 Jun;15(1):1-7.
8. Ahmad Q, Chowdhury SG, Islam MN, Khan FD, Alam MR, Miah AH. HBsAg
amongst unscreened operated patients. Bangladesh Med Res Counc Bull. 1991 Jun;17(1):11-6.
9. Sattar H, Islam MN. Hepatitis B virus markers among the prostitutes of Dhaka. Bangladesh Med Res Counc Bull. 1996 Apr;22(1):8-11.
10. Khan WI, Sultana R, Rahman M, Akhter H, Haq JA, Ali L, et al. Viral hepa¬titis: recent experiences from serological studies in Bangladesh. Asian Pac J Allergy Immunol. 2000 Jun;18(2):99-103.
11. Sabin KM, Rahman M, Hawkes S, Ahsan K, Begum L, Black RE, et al. Sexua¬lly transmitted infections prevalence rates in slum communities of Dhaka, Bangladesh. Int J STD AIDS. 2003 Sep;14(9):614-21.
12. Rumi MA, Siddiqui MA, Salam MA, Iqbal MR, Azam MG, Chowdhury AK, et al. Prevalence of infectious diseases and drug abuse among Bangladeshi workers. Southeast Asian J Trop Med Public Health. 2000 Sep;31(3):571-4.
13. Rahman M, Amanullah, Sattar H, Rahman M, Rashid HA, Mollah AS. Se¬ro-epidemiological study of hepatitis B virus infection in a village. Bangla¬desh Med Res Counc Bull. 1997 Aug;23(2):38-41.
14. Khan M, Haq SA, Ahmed N, Matin MA. Etiology and clinical profile of hepatocellular carcinoma in Bangladesh. Bangladesh Med Res Counc Bull. 1997 Apr;23(1):16-24.
15. Hawkes S. Commentary: Human immunodeficiency virus and hepatitis in Bangladesh: widespread or targeted prevention strategies? Int J Epidemiol. 2001 Aug;30(4):885-6.
16. Laskar MS, Harada N, Khan F. Prevalence of hepatitis B surface antigen (HBsAg) in Viqarunnessa noon girls' school children in Dhaka, Bangladesh. Cent Eur J Public Health. 1997 Dec;5(4):202-4.
17. Ashraf H, Alam NH, Rothermundt C, Brooks A, Bardhan P, Hossain L, et al. Prevalence and risk factors of hepatitis B and C virus infections in an impoverished urban community in Dhaka, Bangladesh. BMC Infect Dis. 2010 Jul 15;10:208.
18. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Stu¬dies in Epidemiology (STROBE) statement: guidelines for reporting observa¬tional studies. PLoS Med. 2007 Oct 16;4(10):e296.
19. Rudra S, Chakrabarty P, Hossain MA, Akhter H, Bhuiyan MR. Seropreva¬lence of hepatitis B, hepatitis C, HIV infections in blood donors of Khulna, Bangladesh. Mymensingh Med J. 2010 Oct;19(4):515-9.
20. Dewan G. Prevalence of hepatitis B and C virus seropositivity among tribal and non-tribal voluntary blood donors of Rangamati, Bangladesh. J Univers Coll of Med Sci. 2013;1(4):33-6.
21. Gibney L, Saquib N, Metzger J, Choudhury P, Siddiqui M, Hassan M. Hu¬man immunodeficiency virus, hepatitis B, C and D in Bangladesh's trucking industry: prevalence and risk factors. Int J Epidemiol. 2001 Aug;30(4):878-84.
22. Shirin T, Ahmed T, Iqbal A, Islam M, Islam MN. Prevalence and risk fac¬tors of hepatitis B virus, hepatitis C virus, and human immunodeficiency virus infections among drug addicts in Bangladesh. J Health Popul. Nutr. 2000 Dec;18(3):145-50.
23. de Francisco A, Hall AJ, Alam N, Hawkes S, Azim T. Hepatitis B infection in Bangladeshi mothers and infants. Southeast Asian J Trop Med Public Health. 1999 Jun;30(2):296-8.
24. Agarwal N, Chatterjee K, Coshic P, Borgohain M. Nucleic acid testing for blood banks: an experience from a tertiary care centre in New Delhi, India. Transfus Apher Sci. 2013 Dec;49(3):482-4.
25. Zaheer HA, Saeed U, Waheed Y, Karimi S, Waheed U. Prevalence and trends of hepatitis B, hepatitis C and human immunodeficiency viruses among blood donors in Islamabad, Pakistan 2005-2013. J Blood Disord Transf. 2014;5(6):217.
26. Liu GC, Sui GY, Liu GY, Zheng Y, Deng Y, Gao YY, et al. A Bayesian me¬ta-analysis on prevalence of hepatitis B virus infection among Chinese vo¬lunteer blood donors. PloS One. 2013 Nov 13;8(11):e79203.
27. Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ. Estimations of world¬wide prevalence of chronic hepatitis B virus infection: a systematic review of
data published between 1965 and 2013. Lancet. 2015 Oct 17;386(10003):1546- 55.
28. Pandeya DR. P3.253 Sero prevalence of HIV, hepatitis B, hepatitis C and syphilis among blood donors in Kathmandu, Nepal. Sex Transm Infect. 2013;89(Suppl 1):A227-8.
29. Ahad MA, Bakar MA, Nazmul Ahsan HA. Pattern of ABO and Rhesus(Rh) blood group among blood donors. J Teach Assoc. 2002;15(2):68-70.
30. Talukder SI, Das RK. Distribution of ABO and Rh blood groups among blood donors of Dinajpur district of Bangladesh. Dinajpur Med Coll J. 2010 Jul;3(2):55-8.
31. Sultana R, Rahman Z, Helali AM, Yousuf R, Mustafa S, Salam A, et al. Study Of ABO and Rh-D blood groups among the common people of capital city of Bangladesh. Int J Pharm Pharm Sci. 2013;5(3):814-6.
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