Gastrointestinal Stromal Tumor: A Case Report

Authors

  • Stefan Krstevski Faculty of Medicine, Saints Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia

DOI:

https://doi.org/10.5195/ijms.2016.164

Keywords:

Gastrointestinal Stromal Tumors, Abdominal Pain, Laparotomy, Early Diagnosis

Abstract

Background: Gastrointestinal stromal tumor (GIST) is a rare gastrointestinal tumor but the most common mesenchymal tumor. It originates in the interstitial cells of Cajal, which on their own membranes have a specific antigen designated as CD117 or KIT receptor, a reliable indicator of tumor detection and therapy.

Case: We reported a case of a 63-year-old male patient, who presented with symptoms of severe abdominal pain, discomfort, and secondary anemia. After a physical examination and a CT scan of the abdomen with angiography, the presence of a large tumor in the right hypochondrium was detected. Blood tests showed a high C-reactive protein and low hemoglobin. The patient had an exploratory laparotomy on his abdomen with complete removal of the tumor growth, which was then histologically analyzed. The obtained result from the histological analysis showed a high-degree of GIST.

Conclusion: Early diagnosis of GISTs is of paramount importance to reduce mortality rate. This requires good background in pathobiology and knowledge of the physical manifestations of this malignant tumor. When this is combined with various imaging techniques, it becomes the gold standard method for GIST diagnosis.

Author Biography

Stefan Krstevski, Faculty of Medicine, Saints Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia

Stefan Krstevski is a sixth-year medical student at Medical Faculty-Skopje R.Macedonia who is interested in the field of Oncology Surgery.

References

1. Nowain A, Bhakta H, Pais S, Kanel G, Verma S. Gastrointestinal stromal tumors: clinical profile, pathogenesis, treatment strategies and prognosis. J Gastroenterol Hepatol. 2005 Jun;20(6):818-24.
2. Min KW, Leabu M. Interstitial cells of Cajal (ICC) and gastrointestinal stro¬mal tumor (GIST): facts, speculations, and myths. J Cell Mol Med. 2006 Oct- Dec;10(4):995-1013.
3. Ward SM, Ordog T, Bayguinov JR, Horowitz B, Epperson A, Shen L, et al. Development of interstitial cells of Cajal and pacemaking in mice lacking enteric nerves. Gastroenterology. 1999 Sep;117(3):584-94.
4. Sanders KM, Ward SM. Interstitial cells of Cajal: a new perspective on smooth muscle function. J Physiol. 2006 Nov 1;576(Pt 3):721-6.
5. Nishida T, Blay JY, Hirota S, Kitagawa Y, Kang YK. The standard diagnosis, treatment, and follow-up of gastrointestinal stromal tumors based on guide¬lines. Gastric Cancer. 2016 Jan;19(1):3-14.
6. Tan CB, Zhi W, Shahzad G, Mustacchia P. Gastrointestinal stromal tumors: a review of case reports, diagnosis, treatment, and future directions. ISRN Gastroenterol. 2012;2012:595968.
7. Eisenberg BL, Pipas JM. Gastrointestinal stromal tumor--background, pa¬thology, treatment. Hematol Oncol Clin North Am. 2012 Dec;26(6):1239-59.
8. Isozaki K, Hirota S. Gain-of-function mutations of receptor tyrosine kinases in gastrointestinal stromal tumors. Curr Genomics. 2006;7(8):469-75.
9. Yan L, Zou L, Zhao W, Wang Y, Liu B, Yao H, et al. Clinicopathological sig¬nificance of c-KIT mutation in gastrointestinal stromal tumors: a systematic review and meta-analysis. Sci Rep. 2015 Sep 9;5:13718.
10. Raghavan D, Blanke CD, Johnson DH, Moots PL, Reaman GH, Rose PG, et al. Textbook of uncommon cancer. 4th ed. New Jersey: Wiley; 2012.

Published

2016-12-25

How to Cite

Krstevski, S. (2016). Gastrointestinal Stromal Tumor: A Case Report. International Journal of Medical Students, 4(3), 120–122. https://doi.org/10.5195/ijms.2016.164

Issue

Section

Case Report