Pulmonary Thromboembolism in Multidrug-Resistant Tuberculosis: A Case Series Highlighting the Importance of Early Diagnosis and Management

Authors

  • Vikas Marwah MD (Pulmonary Medicine), Senior Consultant, Dept of Pulmonary, Critical care and sleep medicine, AICTS, Pune, India.
  • Gaurav Bhati MD (Pulmonary Medicine), Senior resident, Dept of Pulmonary, Critical Care and Sleep Medicine, AICTS, Pune, India.
  • Robin Chaudhary MD (Pulmonary Medicine), Consultant, Dept of Pulmonary, Critical care and sleep medicine, Base Hospital Delhi Cantt, New Delhi, India. https://orcid.org/0000-0002-9641-6849
  • Anmol Sharma MBBS, Resident Internal Medicine, Base Hospital Delhi Cantt, India. https://orcid.org/0000-0003-1184-5298

DOI:

https://doi.org/10.5195/ijms.2023.1996

Keywords:

Tuberculosis burden in low- and middle-income countries, Multidrug-resistant tuberculosis (MDR-TB), Impact of TB on coagulation parameters, Venous thromboembolism (VTE) in acute and chronic infections, Complications of VTE in tuberculosis patients, Pulmonary thromboembolism (PTE) in TB cases, Case studies of MDR pulmonary TB with PTE, Clinical presentation and diagnostic imaging in TB-related PTE, Treatment modalities for TB-related PTE (anticoagulants, thrombolytics), Thrombophilia workup in TB patients with PTE, Hypercoagulable state in tuberculosis, Mechanisms of venous thrombosis in TB patients, Rifampin's role in venous thrombosis, Review of literature on PTE in TB cases in India, Risk factors for PTE in MDR TB patients

Abstract

Background: Pulmonary tuberculosis (PTB) is an established cause of arterial and  venous thrombosis. With the rising incidence of multidrug-resistant tuberculosis (MDR TB), which has a prolonged treatment course, pulmonary thromboembolism in such cases further complicates the treatment outcome in terms of mortality and morbidity. TB causes systemic hypercoagulability, which may lead to both arterial and venous thrombosis. Therefore, it is important for treating physicians to be aware of the entity and have a sharp watch for the development of Pulmonary thromboembolism in cases of MDR TB.

The Case: We present the association of pulmonary thromboembolism (PTE) with MDR TB in three young males who developed pulmonary thromboembolism during the treatment of MDR TB, along with their management using anticoagulant agents.

Conclusion: PTE in cases of TB is rare but fatal. High suspicion of PTE in patients with MDR TB will help in diagnosing the dreaded condition early and aid in reducing preventable mortality with PTE. Early recognition, prompt diagnosis, and management is the key to saving the lives of those with this fatal complication.

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CT Pulmonary Angiogram Showing Thrombo-Embolism in he Right Pulmonary Trunk.

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Published

2023-12-21

How to Cite

Marwah , V., Bhati , G., Chaudhary , R., & Sharma, A. (2023). Pulmonary Thromboembolism in Multidrug-Resistant Tuberculosis: A Case Series Highlighting the Importance of Early Diagnosis and Management. International Journal of Medical Students, 11(4), 321–325. https://doi.org/10.5195/ijms.2023.1996

Issue

Vol. 11 No. 4 (2023)

Section

Case Report

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Copyright (c) 2023 Vikas Marwah , Gaurav Bhati , Robin Chaudhary , Anmol Sharma

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