Dandy-Walker Malformation in an Asymptomatic 27-Year-Old Woman. A Case Report
Keywords:Dandy-Walker Syndrome, Dandy-Walker Variant, Hydrocephalus, Cerebellar Vermis Hypoplasia
Introduction: Dandy-Walker malformation (DWM) is a rare congenital disorder that involves the cerebellum and fourth ventricle. Incidentally detected asymptomatic DWM is sparsely reported in literature at extremes of age (from 1 to 75 years) in association with different diseases. We aim to report the case of a patient with an incidental finding of a DWM after a road traffic accident, reinforcing the importance of suspicion, investigation, diagnosis of clinical presentations.
The Case: This case report describes a 27-year-old female patient who presented to the emergency room after a motor vehicle collision. She suffered a left kidney and spleen injury. The patient’s brain CT scan revealed an enlarged cisterna magna with normal cerebellum, partial hypoplasia of the cerebellar vermis and enlargement of the fourth ventricle compatible with DWM. Neurological examination was unremarkable. An exploratory laparotomy was performed, and the left kidney and spleen showed hemorrhage, so a left nephrectomy and splenectomy was done.
Conclusions: This case report aimed to characterize the DWM, which is a congenital malformation of the central nervous system. Asymptomatic patients do not require surgical treatment; however, these patients should be followed up once a year.
Forzano F, Mansour S, Ierullo A, Homfray T, Thilaganathan B. Posterior fossa malformation in fetuses: a report of 56 further cases and a review of the literature. Prenat Diagn. 2007 Jun;27(6):495-501.
Klein O, Pierre-Kahn A, Boddaert N, Parisot D, Brunelle F. Dandy-Walker malformation: prenatal diagnosis and prognosis. Childs Nerv Syst. 2003 Aug;19(7-8):484-489.
Correa GG, Amaral LF, Vedolin LM. Neuroimaging of Dandy-Walker malformation: new concepts. Top Magn Reson Imaging. 2011 Dec;22(6):303-312.
Maria BL, Zinreich SJ, Carson BC, Rosenbaum AE, Freeman JM. Dandy-Walker syndrome revisited. Pediatr Neurosci. 1987 Feb;13(1):45-51.
Al-Turkistani HK. Dandy–Walker syndrome. J Taibah Univ Sci. 2014 Jul;9(3):209-212.
Ghane VR, Patra KC, Meshram N, Chauhan A, Kalbhande A, Wankhede S. Dandy Walker variant mimicking as cerebral palsy with severe neurological impairment. Int J Res Med Sci. 2014 Aug;2(3):1191-1193.
Andrade N, Karande V. Dandy–Walker Syndrome with Giant Cell Lesions and Cherubism. Ann Maxillofac Surg. 2018 Jan-Jun;8(1):131.
Belfquih H, Elmostarchid B. Asymptomatic Dandy-Walker syndrome in an adult. Pan Afr Med J. 2014 Sep;19.
Tadakamadla J, Kumar S, Mamatha GP. Dandy–Walker malformation: An incidental finding. Indian J Hum Genet. 2010 Jan-Apr;16(1):33-35.
Alexiou GA, Sfakianos G, Prodromou N. Dandy-Walker malformation: analysis of 19 cases. J Child Neurol. 2010 Feb;25(2):188-191.
Dawra RD, Karia S, Shah N, Desousa A. Psychosis in a Case of Dandy-Walker Syndrome: A Case Report. J Clin Diagn Res. 2017 May;11(5): VD03–VD04.
Álvarez E, Schadegg D, Bengaly M, García-Arilla E. [Dandy-Walker syndrome in an independent for basic activities of daily living woman of 85 years old] Rev Esp Geriatr Gerontol. 2018 Mar-Apr;53(2):115-117. Spanish
Leibovitz Z, Haratz KK, Malinger G, Shapiro I, Pressman C. Fetal posterior fossa dimensions: normal and anomalous development assessed in mid-sagittal cranial plane by three-dimensional multiplanar sonography. Ultrasound Obstet Gynecol. 2014 Feb;43(2):147-153.
Gandolfi Colleoni G, Contro E, Carletti A, Ghi T, Campobasso G, Rembouskos G, Volpe G, Pilu G, Volpe P. Prenatal diagnosis and outcome of fetal posterior fossa fluid collections. Ultrasound Obstet Gynecol. 2012 Jun;39(6):625-631.
Jurcă MC, Kozma K, Petcheşi CD, Bembea M, Pop OL, MuŢiu G, Coroi MC, Jurcă AD, Dobjanschi L. Anatomic variants in Dandy-Walker complex. Rom J Morphol Embryol. 2017 Sep;58(3):1051-1055.
Aminoff M, Daroff R. Encyclopedia Of The Neurological Sciences. 2nd ed. Burlington: Elsevier Science; 2014 May; p.935-941.
Li J, Hu Q, Yan F, Shrestha S, Chen G. An Asymptomatic Dandy-Walker Malformation—A Case Report and Literature Review. Neurosurg Q. 2016 Feb;26(1):87-89
How to Cite
Authors who publish with this journal agree to the following terms:
- The Author retains copyright in the Work, where the term “Work” shall include all digital objects that may result in subsequent electronic publication or distribution.
- Upon acceptance of the Work, the author shall grant to the Publisher the right of first publication of the Work.
- The Author shall grant to the Publisher and its agents the nonexclusive perpetual right and license to publish, archive, and make accessible the Work in whole or in part in all forms of media now or hereafter known under a Creative Commons Attribution 4.0 International License or its equivalent, which, for the avoidance of doubt, allows others to copy, distribute, and transmit the Work under the following conditions:
- Attribution—other users must attribute the Work in the manner specified by the author as indicated on the journal Web site; with the understanding that the above condition can be waived with permission from the Author and that where the Work or any of its elements is in the public domain under applicable law, that status is in no way affected by the license.
- The Author is able to enter into separate, additional contractual arrangements for the nonexclusive distribution of the journal's published version of the Work (e.g., post it to an institutional repository or publish it in a book), as long as there is provided in the document an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post online a prepublication manuscript (but not the Publisher’s final formatted PDF version of the Work) in institutional repositories or on their Websites prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work. Any such posting made before acceptance and publication of the Work shall be updated upon publication to include a reference to the Publisher-assigned DOI (Digital Object Identifier) and a link to the online abstract for the final published Work in the Journal.
- Upon Publisher’s request, the Author agrees to furnish promptly to Publisher, at the Author’s own expense, written evidence of the permissions, licenses, and consents for use of third-party material included within the Work, except as determined by Publisher to be covered by the principles of Fair Use.
- The Author represents and warrants that:
- the Work is the Author’s original work;
- the Author has not transferred, and will not transfer, exclusive rights in the Work to any third party;
- the Work is not pending review or under consideration by another publisher;
- the Work has not previously been published;
- the Work contains no misrepresentation or infringement of the Work or property of other authors or third parties; and
- the Work contains no libel, invasion of privacy, or other unlawful matter.
- The Author agrees to indemnify and hold Publisher harmless from the Author’s breach of the representations and warranties contained in Paragraph 6 above, as well as any claim or proceeding relating to Publisher’s use and publication of any content contained in the Work, including third-party content.
Enforcement of copyright
The IJMS takes the protection of copyright very seriously.
If the IJMS discovers that you have used its copyright materials in contravention of the license above, the IJMS may bring legal proceedings against you seeking reparation and an injunction to stop you using those materials. You could also be ordered to pay legal costs.
If you become aware of any use of the IJMS' copyright materials that contravenes or may contravene the license above, please report this by email to email@example.com
If you become aware of any material on the website that you believe infringes your or any other person's copyright, please report this by email to firstname.lastname@example.org