Correlation of Fine Needle Aspiration Cytology and Histopathology Diagnosis in the Evaluation of Breast Lumps
Keywords:Breast Neoplasms, biopsy, Cytological Techniques, Fine-Needle Biopsy
Background: A large number of patients have been suffer from breast cancer worldwide and this trend is increasing. It is difficult to determine whether a lump is benign or malignant from clinical assessment; thus, the need for micropic and tissue analysis arises. Methods: This comparative retrospective cross sectional study was conducted in the Department of Pathology, Rehman Medical Institute, Peshawar, Pakistan from January 2006 to March 2013, to determine the value of fine needle aspiration cytology (FNAC) in the diagnosis of breast lump and to compare the result of FNAC with histological diagnosis to assess its accuracy. Results: Seventy-four cases with breast lumps were presented for FNAC. Of these, 32.4% were reported as a C2 lesion, 4.1% were reported as benign with atypical cells (C3), 8.1% cases were suspicious for malignancy (C4), and 55.4% were positive for malignancy (C5). On histopathology examination, out of 24 cases which were reported as C2 lesions, 95.8% were benign and 4.1% turned out to be invasive ductal carcinoma. Of the cases that presented as C3 lesions, one was diagnosed as benign duct ectasia, one with ductal carcinoma in situ, and one with invasive ductal carcinoma on histopathological examination. The cases that were diagnosed as C4 lesions all turned out to be carcinoma on histopathology. In this study, FNAC and histopathology diagnoses were strongly correlated [r 0.92, p <0.001]. Conclusion: Diagnosis of breast lump based on FNAC should be practiced as there is high correlation with histopathological finding. FNAC should be used as a routine...
2. Aslam S, Hameed S, Afzal T, Hussain A, Zafar H, Naz M, et al. Correlation of FNAC and Histological diagnosis in the evaluation of breast lumps. JUMDC. 2012 Jul-Dec;3(2):1-7.
3. Khemka A, Chakrabarti N, Shah S, Patel V. Palpable Breast Lumps: Fi¬ne-Needle Aspiration Cytology versus Histopathology: a Correlation of Diag¬nostic Accuracy. Internet Journal of Surgery. 2009;18(1).
4. Qureshi H, Amanullah A, Khan KM, Deeba F. Efficacy of fine needle aspira¬tion cytology in the diagnosis of breast lumps. JPMI. 2011;21(4):301-4.
5. Yong W, Chia K, Poh W, Wong C. A comparison of trucut biopsy with fine needle aspiration cytology in the diagnosis of breast cancer. Singapore Med J. 1999 Sep;40(9):587-9.
6. Rahman S, Ali M, Khalili Y, Ali A, Lal A. Role of fine needle asporation cyto¬logy in evaluating the breast lumps. Gomal J Med Sci. 2011 Jan-Jun;9(1):59-61.
7. Baak J.P.A. The relative prognostic significance of nucleolar morphology in invasive ductal breast cancer. Histopathology. 1985 Apr;9(4):437-44.
8. Boerner S, Sneige N. Specimen adequacy and false-negative diagnosis rate in fine-needle aspirates of palpable breast masses. Cancer. 1998 Dec 25;84(6):344-8..
9. Feichter GE, Haberthür F, Gobat S, Dalquen P. Breast cytology. Acta cytolo¬gica. 1997 Mar-Apr;41(2):327-32.
10. Bajwa R, Zulfiqar T. Association of fine needle aspiration cytology with tumor size in palpable breast lesions. Biomedica. 2010 Jul-Dec;26:124-9.
11. Wilkinson EJ, Bland KI. Techniques and results of aspiration cytology for diagnosis of benign and malignant diseases of the breast. Surg Clin North Am. 1990 Aug;70(4):801-13.
12. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observa¬tional studies. PLoS Med. 2007 Oct 16;4(10):e296.
13. IBM Corp. Released 2011. IBM SPSS Statistics for Windows, Version 20.0. Armonk, NY: IBM Corp.
14. Sohail S, Alam SN. Breast cancer in pakistan-awareness and early de¬tection. Journal of the College of Physicians and Surgeons--Pakistan: JJ Coll Physicians Surg Pak. 2007 Dec;17(12):711-2.
15. Nasuti JF, Gupta PK, Baloch ZW. Diagnostic value and cost-effectiveness of on-site evaluation of fine-needle aspiration specimens: review of 5,688 cases. Diagn Cytopathol. 2002 Jul;27(1):1-4.
16. Rupom TU, Choudhury T, Banu SG. Study of Fine Needle Aspiration Cyto¬logy of Breast Lump: Correlation of Cytologically Malignant Cases with Their Histological Findings. BSMMU J. 2011;4(2):60-64.
17. Waqar AJ, Zada N and Israr M. Comparison of FNAC and core needle biopsy for evaluating breast lumps. JCPSP. 2002; 12: 686-8.
18. Gukas I, Nwana E, Ihezue C, Momoh J, Obekpa P. Tru-cut biopsy of palpa¬ble breast lesions: a practical option for pre-operative diagnosis in develo¬ping countries. Cent Afr J Med. 2000 May;46(5):127-30.
19. Tiryaki T, Senel E, Hucumenoglu S, Cakir BC, Kibar AE. Breast fibroadeno¬ma in female adolescents. Saudi Med J. 2007 Jan;28(1):137-8.
20. Guray M, Sahin AA. Benign breast diseases: classification, diagnosis, and management. Oncologist. 2006 May;11(5):435-49.
21. Bukhari MH, Arshad M, Jamal S, Niazi S, Bashir S, Bakhshi IM. Use of fine-needle aspiration in the evaluation of breast lumps. Patholog Res Int. 2011;2011:689521.
22. Bakhos R, Selvaggi SM, DeJong S, Gordon DL, Pitale SU, Herrmann M, Wojcik EM. Fine-needle aspiration of the thyroid: rate and causes of cytohistopathologic discordance. Diagn Cytopathol. 2000 Oct;23(4):233-7.
23. Bagga PK, Mahajan NC. Fine needle aspiration cytology of thyroid swellings: how useful and accurate is it?. Indian J Cancer. 2010 Oct-Dec;47(4):437-42.
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