A Systematic Review of Cerebral Arteriovenous Malformation Management


  • Karen Eliahu Human Development and Aging, Davis School of Gerontology, University of Southern California, Los Angeles, United States of America.
  • Florence Hofman Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, United States of America.
  • Steven Giannotta Department of Neurosurgery, University of Southern California, Los Angeles, California, United States of America.




Intracranial Arteriovenous Malformations, Hemangioma, Cavernous, Central Nervous System, Precision Medicine, Gene Knockout Techniques, Patient Selection


Cerebral Arteriovenous Malformation is a neurovascular lesion characterized by an abnormal connection between arterial and venous systems, resulting in a tangle of blood vessels lacking intervening capillaries. The goal of treatment is to prevent catastrophic hemorrhage, neurological injury, or death. Despite the availability of multiple cutting-edge treatment options there is little consensus on the most promising approaches for treatment due to the novelty of each Arteriovenous Malformation case. This analysis will link the various angioarchitectural characteristics and associated presentations of Arteriovenous Malformation to treatment modalities. In the era of personalized medicine, genomics-driven research to normalize by drawing parallels between Cerebral Cavernous Malformation and Arteriovenous Malformation, both of which are characterized by hemorrhage-prone vascular malformations, may provide insight for the development of pharmacological therapy. Understanding the underlying mechanisms and genes responsible for the symptoms will allow us to better treat patients in a non-invasive manner and paves future directions in Arteriovenous Malformation treatment.


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How to Cite

Eliahu, K., Hofman, F., & Giannotta, S. (2017). A Systematic Review of Cerebral Arteriovenous Malformation Management. International Journal of Medical Students, 5(2), 74–80. https://doi.org/10.5195/ijms.2017.13