Using Oral and Intranasal Dosage Forms of Ketamine for Managing Treatment-Resistant Depression: A Review of the Literature

Authors

  • Patrick Arthur Twohig Saba University School of Medicine, Caribbean Netherlands.
  • Vaughn Huckfeldt Saba University School of Medicine, Caribbean Netherlands.

DOI:

https://doi.org/10.5195/ijms.2016.153

Keywords:

Ketamine, Depressive Disorder, Treatment-Resistant, Administration, Oral, Administration, Intranasal, Intravenous

Abstract

A lack of effective treatment for patients with treatment-resistant depression (TRD) has led to the evaluation of ketamine, an N-methyl- D-aspartate receptor antagonist. Despite the demonstrated short-term benefits of using intravenous (IV) ketamine, side effects and the difficulty in administering ketamine outside the health-care setting has raised interest in alternative dosage forms. Research articles evaluating oral or intranasal (IN) ketamine were retrieved from the PubMed database. Patients who received oral or IN ketamine experienced a similar reduction in depressive symptoms within 24 hours of treatment and fewer side effects compared to patients who received IV ketamine. Novel administration forms of ketamine provide an opportunity for patients with TRD to achieve remission with fewer adverse side effects. Future studies should continue to evaluate these administration strategies in the hope of promoting ketamine’s use outside health-care settings and for longer time periods.

Author Biography

Patrick Arthur Twohig, Saba University School of Medicine, Caribbean Netherlands.

Patrick Twohig is currently a fourth- year medical student at Saba University School of Medicine, graduating in 2017. He completed his undergraduate studies and MPH in Canada.

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Published

2016-07-27

How to Cite

Arthur Twohig, P., & Huckfeldt, V. (2016). Using Oral and Intranasal Dosage Forms of Ketamine for Managing Treatment-Resistant Depression: A Review of the Literature. International Journal of Medical Students, 4(2), 64–71. https://doi.org/10.5195/ijms.2016.153

Issue

Section

Review