Comparing Treatment Recommendations for Ten Dermatological Conditions Using ChatGPT, Claude, and PI AI Models
Keywords:
acne, Machine leaning, Actinic keratosis, Carcinoma,, DermatologyAbstract
BACKGROUND: Artificial Intelligence (AI) is being increasingly utilized in healthcare and offers a potential alternative for gathering medical information in the future. The gold standard for many physicians on guiding their approach to medical management has been UpToDate and PubMed. In this review we attempted to see how well three AI models (ChatGPT, Pi, and Claude) could perform in generating first line treatment recommendations when compared against UpToDate.
METHODS: To test the performance of these AI models, medical scenarios describing physical exam findings and patient histories, were sourced from the clinician generated medical education platform for ten dermatological diseases and inputted into the models. The models were then prompt with the query: “What is the first line treatment?”
RESULTS: The results were tabulated, and it was found that Claude could successfully generated first line treatment recommendations that corresponded to UpToDate for all ten of the diseases tested with the other models successfully predicting nine of the ten correct treatment regimes. However, ChatGPT and Pi mistakenly diagnosed the squamous cell carcinoma vignette as actinic keratosis and provided inaccurate treatment advice.
CONCLUSION: These AI models demonstrate that future developments in artificial intelligence may offer a free alternative to UpToDate as improvements in management recommendations are made as artificial intelligence models are further refined. However, the benefits of future utilization must be weighed against the risks of overreliance on this type of technology, especially if proper validation of information does not take place.
References
Marchetti MA, Cowen EA, Kurtansky NR, Weber J, Dauscher M, DeFazio J, et al. Prospective validation of dermoscopy-based open-source artificial intelligence for melanoma diagnosis (PROVE-AI study). NPJ Digital Medicine. 2023;6(1):127.
Addison J, Whitcombe J, William Glover S. How doctors make use of online, point‐of‐care clinical decision support systems: a case study of UpToDate©. Health Information & Libraries Journal. 2013;30(1):13-22.
Grada A, Muddasani S, Fleischer Jr AB, Feldman SR, Peck GM. Trends in office visits for the five most common skin diseases in the United States. The Journal of Clinical and Aesthetic Dermatology. 2022;15(5):E82.
Feldman SR, Fleischer AB, McConnell RC. Most common dermatologic problems identified by internists, 1990-1994. Archives of internal medicine. 1998;158(7):726-30.
Tucker R. Case-based learning: acne vulgaris [Available from: https://pharmaceutical-journal.com/article/ld/case-based-learning-acne-vulgaris.
Epocrates About [Available from: https://www.epocrates.com/about]. cited April 1, 2024
Graber E. Acne vulgaris: Overview of management 2024 [Available from: https://www.uptodate.com/contents/acne-vulgaris-overview-of-management.
Brod B. Management of allergic contact dermatitis in adults 2024 [Available from: https://www.uptodate.com/contents/management-of-allergic-contact-dermatitis-in-adults?search=contact%20dermatitis%20managment&source=search_result&selectedTitle=2%7E150&usage_type=default&display_rank=2.
Berman B. Treatment of actinic keratosis 2024 [Available from: https://www.uptodate.com/contents/treatment-of-actinic-keratosis?search=actinic%20keratosis&source=search_result&selectedTitle=1%7E110&usage_type=default&display_rank=1#H1989203002.
Sumaira Aasi AH. Treatment and prognosis of low-risk cutaneous squamous cell carcinoma (cSCC) 2024 [Available from: https://www.uptodate.com/contents/treatment-and-prognosis-of-low-risk-cutaneous-squamous-cell-carcinoma-cscc?search=squamous%20cell%20carcinoma%20management&source=search_result&selectedTitle=1%7E150&usage_type=default&display_rank=1.
Aasi S. Treatment and prognosis of basal cell carcinoma at low risk of recurrence 2024 [Available from: https://www.uptodate.com/contents/treatment-and-prognosis-of-basal-cell-carcinoma-at-low-risk-of-recurrence?search=basal%20cell%20carcinoma%20management&source=search_result&selectedTitle=1%7E150&usage_type=default&display_rank=1#H4133726805.
Baddour DSL. Acute cellulitis and erysipelas in adults: Treatment 2024 [Available from: https://www.uptodate.com/contents/acute-cellulitis-and-erysipelas-in-adults-treatment?search=cellulitis%20treatment&source=search_result&selectedTitle=2%7E150&usage_type=default&display_rank=2.
Michael Hertl SG. Initial management of pemphigus vulgaris and pemphigus foliaceus 2024 [Available from: https://www.uptodate.com/contents/initial-management-of-pemphigus-vulgaris-and-pemphigus-foliaceus?search=pemphigus%20vulgaris&source=search_result&selectedTitle=1%7E54&usage_type=default&display_rank=1#H806899198.
Sasseville D. Seborrheic dermatitis in adolescents and adults 2024 [Available from: https://www.uptodate.com/contents/seborrheic-dermatitis-in-adolescents-and-adults?search=seborrheic%20dermatitis%20treatment&source=search_result&selectedTitle=1%7E150&usage_type=default&display_rank=1#H1431767.
Maier L. Management of rosacea 2022 [Available from: https://www.uptodate.com/contents/management-of-rosacea?search=rosacea%20treatment&source=search_result&selectedTitle=1%7E123&usage_type=default&display_rank=1#H2324949.
Jeff Donovan BG, Adam Goldstein. Male pattern hair loss (androgenetic alopecia in males): Management 2023 [Available from: https://www.uptodate.com/contents/male-pattern-hair-loss-androgenetic-alopecia-in-males-management?search=androgenetic%20alopecia%20treatment&source=search_result&selectedTitle=1%7E31&usage_type=default&display_rank=1.
OpenAI. Introducing ChatGPT [Available from: https://openai.com/blog/chatgpt]. Last Updated November 22, 2022; cited April 1, 2024
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