Prognostic Factors in Patients with Rocky Mountain Spotted Fever
Background: Rocky Mountain Spotted Fever (RMSF) is a disease with a high mortality rate, caused by Rickettsia rickettsii, a bacteria transmitted to humans by infected ticks. In 2008 there was a Rocky Mountain Spotted Fever (RMSF) outbreak in the city of Mexicali, México, resulting in an increased mortality rate amongst the area population.
Methods: Case-series study of patients admitted to the General Hospital of Mexicali between 2014 and 2019 with a confirmed diagnosis of RMSF. Mortality was compared dividing the population on those ≤20 and younger than ˃21 years of age.
Results: A total of 129 patients’ records during a 5-year period whose diagnosis was RMSF confirmed with PCR were included. Mortality was compared among patients admitted who were younger than ≤20 years of age with that among patients who were older than ˃20 years of age (61 versus 68 respectively), the latter being higher with an OR 4.2 (p<0.0001).
Conclusion: RMSF in hospitalized patients has a high mortality rate in spite of early treatment in all age groups, without showing any predominance in gender. However, patients older than 20 years of age had a higher mortality rate than those younger than 20 years, without any predominance in gender.
Snowden S, Simonsen KA. Rickettsia Rickettsiae (Rocky Mountain Spotted Fever). StatPearls Publishing; 2020.
Sanchez-Montes S, Lopez-Perez AM, Guzman-Cornejo C, Colunga-Salas P, Becker I, Delgado-de la Mora- J, et al. Rickettsia parkeri in Dermacentor parumapertus Ticks, México. Emerg Infect Dis. 2018 Jun;24(6):1108-1111.
Álvarez-Hernández G, Candia-Plata MC, Delgado-de la Mora J, Acuña-Melendrez NH, Vargas-Ortega AP, Licona-Enríquez JD. Fiebre maculosa de las Montañas Rocosas en niños y adolescentes mexicanos: cuadro clinico y factores de mortalidad Salud Publica Mex 2016;58:385-392. Spanish.
Pavanelo DR, Schroder NCH, Pin Viso ND, Martins LA, Malossi CD, Galleti MFBM, et al. Comparative analysis of the midgut microbiota of two natural tick vector of Rickettsia rickettsia. Dev Comp Immunol. 2020; 106:103606.
Barba JR. Fiebre manchada de las Montañas Rocosas. Revista Mexicana de Patologia Clinica. 2009; 56(3):193-208. Spanish.
Parola P, Paddock CD, Socolovschi C, Labruna MB, Mediannikov O, Kernif T, et al. Update on Tick-Borne Rickettsioses around the World: a Geographic Approach. Clin Microbiol Rev. 2013;26(4):657–702.
Traeger MS, Regan JJ, Humpherys D, Mahoney DL, Martinez M, Emerson GL, et al. Risk Factors for Fatal Outcome From Rocky Mountain Spotted Fever in a Highly Endemic Area—Arizona, 2002–2011. Clin Infect Dis. 2015; 60(11):1659–66.
Jaramillo HJ, Rodriguez M. Ricketsiosis. Presentacion de dos casos, en medio de un brote en Mexicali, Baja California. Medicina Interna de México. 2010; 26(2):180-2. Spanish.
Paddock CD, Denison AM, Lash RR, Liu L, Bollweg BC, Dahlgren FS. Phylogeography of Rickettsia rickettsii Genotypes Associated with Fatal Rocky Mountain Spotted Fever. Am J Trop Med Hyg. 2014;91(3):589-97.
Gottlieb M, Long B, Koyfman A. The Evaluation and Management of Rocky Mountain Spotted Fever in the Emergency Department: a Review of the Literature. J Emerg Med. 2018 Jul;55(1):42-50.
Moore JJ. Time relationships of the wood-tick in the transmission of Rocky Mountain spotted fever. J Infect Dis 1911; 8: 339–47.
Ramos-e-Silva M, Pereira AL. Life Threatening Eruptions Due to Infectious Agents. Clin Dermatol. 2005; 23(2):148-56.
Denison AM, Amin BD, Nicholson WL, Paddock CD. Detection of Rickettsia rickettsii, Rickettsia parkeri, and Rickettsia akari in skin biopsy specimens using a multiplex real-time polymerase chain reaction assay. Clin Infec Dis. 2014; 59(5):635-642.
Centers for Disease Control and Prevention. Available from: https://www.cdc.gov/dpdx/ticks/index.html. Atlanta: c2019. Cited Nov 19, 2019.
Ed. E. Maxey, G T McCullough, J W Leary. Some Observations on the So-called Spotted Fever of Idaho. 1st ed. 1899.
Copyright (c) 2020 Hiram J. Jaramillo-Ramírez, Jeremy J. Hernández-Ríos, Fátima M. Martínez-González, Luz A. Gutiérrez-Bañales, Eliot R. García-Valenzuela, J. Andrés Beltrán-López, Jorge L. Peterson, Flor M. Yocupicio, Rodolfo Ruíz-Luján
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